新型氮杂螺烷SK&F 105685的治疗活性，其具有诱导抑制细胞的活性。
Therapeutic activity of SK&F 105685, a novel azaspirane with suppressor-cell inducing activity.
作者信息
Badger A M, Swift B A
机构信息
Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406.
出版信息
Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S107-9.
SK&F 105685, methotrexate (MTX) and chloroquine (CHL) were examined for their ability to inhibit paw inflammation in the adjuvant arthritic rat (AA) and for their ability to induce non-specific suppressor cells (SC) in the spleens of these animals. Compared to SK&F 105685 (84-90%) inhibition and MTX (91% inhibition) CHL, at the maximally tolerated dose, only inhibited paw lesions by 29%. MTX did not induce splenic SC activity and, despite the structural similarities between CHL and SK&F 105685, only the latter induced suppressor cells.
对SK&F 105685、甲氨蝶呤（MTX）和氯喹（CHL）进行了研究，观察它们抑制佐剂性关节炎大鼠（AA）爪部炎症的能力，以及诱导这些动物脾脏中非特异性抑制细胞（SC）的能力。与SK&F 105685（抑制率84 - 90%）和MTX（抑制率91%）相比，CHL在最大耐受剂量时仅抑制爪部损伤29%。MTX未诱导脾脏SC活性，尽管CHL与SK&F 105685结构相似，但只有后者诱导出抑制细胞。
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