肾功能不全与磷霉素

Renal insufficiency and fosfomycin.

作者信息

Gobernado M, García J, Santos M, Panadero J, Diosdado N

出版信息

Chemotherapy. 1977;23 Suppl 1:200-3. doi: 10.1159/000222048.

DOI:10.1159/000222048

Abstract

After the parenteral injection of 1 g sodium salt of fosfomycin the serum levels of the antibiotic are detected in a series of eight adult patients with different degrees of chronic renal insufficiencies four of them submitted to periodical dialysis. The results obtained reveal that the levels as well as the time of elimination of fosfomycin maintain an obvious relation to the degree of renal insufficiency in the patients.

摘要

对8例不同程度慢性肾功能不全的成年患者（其中4例接受定期透析）进行静脉注射1g磷霉素钠盐后，检测其血清中抗生素水平。所得结果显示，磷霉素的血药水平及其消除时间与患者肾功能不全的程度存在明显关联。