携带促吞噬肽的脂质体作为治疗实验性曲霉病的药物载体。
Tuftsin-bearing liposomes as drug vehicles in the treatment of experimental aspergillosis.
作者信息
Owais M, Ahmed I, Krishnakumar B, Jain R K, Bachhawat B K, Gupta C M
机构信息
Institute of Microbial Technology, Chandigarh, India.
出版信息
FEBS Lett. 1993 Jul 12;326(1-3):56-8. doi: 10.1016/0014-5793(93)81760-w.
PMID:8325389
Abstract
Encapsulation of amphotericin B in tuftsin-bearing liposomes greatly increased its efficacy in treatment of human aspergillosis in mice. Also, the drug efficacy was significantly increased by pretreating the animals with drug-free tuftsin-bearing liposomes. These results demonstrate that macrophage activation can considerably enhance the therapeutic efficacy of antifungal drugs, like amphotericin B.
摘要
将两性霉素B包裹于携带促吞噬肽的脂质体中，可显著提高其对小鼠人类曲霉病的治疗效果。此外，用不含药物的携带促吞噬肽的脂质体预处理动物，药物疗效也显著提高。这些结果表明，巨噬细胞激活可显著增强两性霉素B等抗真菌药物的治疗效果。
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