Sole Puyo J M, Poch Viñals R
Chemotherapy. 1977;23 Suppl 1:379-91. doi: 10.1159/000222079.
A group of 24 patients with suppurated chronic processes of the medial ear have been treated with fosfomycin. All the cases were studied bacteriologically, isolating in the pus or exudates pathogenic bacterial flora, in which P. aeruginosa (40%) of the isolations) and S. aureus (23%) predominated. The sensitiveness of the strains isolated to fosfomycin was 94%. The results obtained were 21 clinical cures accompanied by the sterility of the exudates and 3 failures, which represents 87.5% success and 12.5% failures. These results are considered very satisfactory in view of the complexity and chronicity of the processes treated. It is also pointed out that fosfomycin totally lacks ototoxicity, being, therefore, a suitable antibiotic for treating chronic infectious processes of the ear.
一组24例患有中耳慢性化脓性病变的患者接受了磷霉素治疗。所有病例均进行了细菌学研究，在脓液或渗出物中分离出致病性细菌菌群，其中铜绿假单胞菌（占分离菌的40%）和金黄色葡萄球菌（占23%）占主导。分离出的菌株对磷霉素的敏感性为94%。获得的结果是21例临床治愈，渗出物无菌，3例失败，成功率为87.5%，失败率为12.5%。鉴于所治疗疾病的复杂性和慢性，这些结果被认为非常令人满意。还指出磷霉素完全没有耳毒性，因此是治疗耳部慢性感染性疾病的合适抗生素。
