Hernández Casado V
Chemotherapy. 1977;23 Suppl 1:403-10. doi: 10.1159/000222082.
Fosfomycin has been used in the treatment of 99 patients suffering from varying kinds of osseous processes and divided into 2 groups, one of 60 patients who were not operated on, and another of 39 who were operated. A treatment only with fosfomycin was tried initially by intravenous infusion (8-16 g/day during 2-4 days), then by the intramuscular route (2-8 g/day during 2-6 days) and finishing with treatment by the oral route (2-4 g/day during 2-6 days). The results have been excellent, all cases progressing with no septic complications. As for secondary effects, we have had only one case in which a rash appeared at the end of treatment. Intravenous infusion has been well tolerated with no sign of phlebitis in any patient.
磷霉素已用于治疗99例患有各种骨病的患者，并将其分为两组，一组60例未接受手术，另一组39例接受了手术。最初尝试仅用磷霉素进行静脉输注治疗（2至4天内每天8 - 16克），然后通过肌肉注射途径（2至6天内每天2 - 8克），最后通过口服途径治疗（2至6天内每天2 - 4克）。结果非常好，所有病例均无败血症并发症进展。至于副作用，我们仅有1例在治疗结束时出现皮疹。静脉输注耐受性良好，所有患者均未出现静脉炎迹象。
