Gallardo A, Sáez J M, Enriquez G, Cobacho A R, Torronteras R, Recordan C, Del Moral A, Arroyo A, Curiel A G
Chemotherapy. 1977;23 Suppl 1:392-8. doi: 10.1159/000222080.
Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic of soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominantly S. aureus and E. coli, all the isolated species appeared to be sensitive to fosfomycin. In the second group a gram-negative bacterial flora predominantly E. coli was obtained; with a sensitivity to this antibiotic of 90.5%. Surgical treatment accompanied the treatment with fosfomycin. In the first group, all the patients were cured with the oral administration of 2-6 g/day and in an average time less than that of the similar control group which did not receive the antibiotic. In the second group surgical treatment was necessary in 25 of the 29 patients and in all of them parenteral treatment was done with fosfomycin, preferably intramuscularly and in general the dosage was 4 g daily. All patients were cured except for one who was not operated on and who suffered from a fever of undetermined origin.
两组患有外科感染的患者接受了磷霉素治疗。第一组包括21例化脓性真皮及皮下软组织病变患者。第二组包括29例外科腹部感染患者。第一组的细菌学检查发现主要为革兰氏阳性菌和革兰氏阴性菌，以金黄色葡萄球菌和大肠杆菌为主，所有分离出的菌种对磷霉素均敏感。第二组获得了以大肠杆菌为主的革兰氏阴性菌菌群，对该抗生素的敏感性为90.5%。在使用磷霉素治疗的同时进行了外科治疗。在第一组中，所有患者口服每日2 - 6克磷霉素均治愈，且平均治愈时间短于未接受抗生素治疗的类似对照组。在第二组的29例患者中，有25例需要进行外科治疗，所有这些患者均采用磷霉素进行非肠道给药治疗，最好是肌肉注射，一般剂量为每日4克。除1例未接受手术且患有不明原因发热的患者外，所有患者均治愈。
