Kuwano H, Baba K, Ikebe M, Adachi Y, Toh Y, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hepatogastroenterology. 1993 Jun;40(3):222-5.
To examine the histogenesis of esophageal cancer and the pathological relationship between dysplasia and carcinoma of the esophagus, 44 cases of superficial esophageal carcinoma (restricted to within the submucosal layer) who received no pre-operative treatment were reviewed retrospectively. There were 40 dysplastic lesions in 17 cases (38.6%) and epithelial dysplastic lesions were classified into 6 with mild, 17 with moderate and 17 with severe, degrees of dysplasia. Although the continuity of dysplastic lesions with the carcinomatous areas was not frequent (35.0%), it was more often encountered in severe dysplasia than in moderate or mild dysplasia, suggesting some relationship between the severity of dysplasia and carcinoma. In the cases with a dysplastic lesion, multiplicity of squamous cell carcinoma was more frequently seen (p < 0.01), suggesting a multicentric occurrence of dysplastic lesions and carcinomas.
为研究食管癌的组织发生以及食管发育异常与癌之间的病理关系，我们回顾性分析了44例未接受术前治疗的浅表性食管癌（局限于黏膜下层）患者。17例患者（38.6%）存在40处发育异常病变，上皮发育异常病变分为轻度6处、中度17处、重度17处。虽然发育异常病变与癌灶的连续性并不常见（35.0%），但在重度发育异常中比中度或轻度发育异常更常出现，提示发育异常的严重程度与癌之间存在某种关系。在有发育异常病变的病例中，更常出现鳞状细胞癌的多灶性（p<0.01），提示发育异常病变和癌多中心发生。
