Uno H, Kurata S
Wisconsin Regional Primate Research Center, Madison 53715-1299.
J Invest Dermatol. 1993 Jul;101(1 Suppl):143S-147S. doi: 10.1111/1523-1747.ep12363275.
During the past decade we have examined both the therapeutic and the prophylactic effects of several agents on the macaque model of androgenetic alopecia. Minoxidil and diazoxide, potent hypotensive agents acting as peripheral vasodilators, are known to have a hypertrichotic side effect. Topical use of both agents induced significant hair regrowth in the bald scalps of macaques. The application of a steroid 5 alpha-reductase inhibitor (4MA) in non-bald preadolescent macaques has prevented baldness, whereas controls developed it during 2 years of treatment. The effects of hair growth were determined by 1) phototrichogram, 2) folliculogram (micro-morphometric analysis), and 3) the rate of DNA synthesis in the follicular cells. These effects were essentially a stimulation of the follicular cell proliferation, resulting in an enlargement of the anagen follicles from vellus to terminal type (therapy) or a maintenance of the prebald terminal follicles (prevention). A copper binding peptide (PC1031) had the effect of follicular enlargement on the back skin of fuzzy rats, covering the vellus follicles; the effect was similar to that of topical minoxidil. Analyzing the quantitative sequences of follicular size and cyclic phases, we speculate on the effect of agents on follicular growth. We also discuss the triggering mechanism of androgen in the follicular epithelial-mesenchymal (dermal papilla) interaction.
在过去十年中，我们研究了几种药物对雄激素性脱发猕猴模型的治疗和预防作用。米诺地尔和二氮嗪是强效降压药，作为外周血管扩张剂，已知有毛发增多的副作用。局部使用这两种药物均可使猕猴秃头皮显著再生毛发。在未秃的青春期前猕猴中应用类固醇5α-还原酶抑制剂（4MA）可预防脱发，而对照组在两年的治疗期间出现了脱发。通过以下方法确定毛发生长效果：1）毛发照片，2）毛囊图（微观形态计量分析），3）毛囊细胞中的DNA合成速率。这些效果本质上是刺激毛囊细胞增殖，导致生长期毛囊从毳毛型增大为终毛型（治疗）或维持脱发前的终毛毛囊（预防）。一种铜结合肽（PC1031）对覆盖毳毛毛囊的绒毛鼠背部皮肤有毛囊增大作用；其效果与局部使用米诺地尔相似。通过分析毛囊大小和周期阶段的定量序列，我们推测了药物对毛囊生长的作用。我们还讨论了雄激素在毛囊上皮-间充质（真皮乳头）相互作用中的触发机制。
