Nielsen S V, Sørensen U B, Henrichsen J
World Health Organization Collaborating Centre for Reference and Research on Pneumococci, Statens Seruminstitut, Copenhagen, Denmark.
Microb Pathog. 1993 Apr;14(4):299-305. doi: 10.1006/mpat.1993.1029.
The ability of antibodies against C-polysaccharide (C-Ps) to protect against experimental pneumococcal infection was examined in a mouse model. No protection against types 6A and 14 pneumococcal infection could be demonstrated neither with mouse monoclonal antibodies against C-Ps, specific for phosphorylcholine (PC) or for C-Ps backbone, nor for polyclonal rabbit immunsera against C-Ps. The monoclonal antibody with PC-specificity was protective against infection with type 27 pneumococcus, that has PC as part of its capsular polysaccharide. Type-specific mono- and polyclonal antibodies were highly protective against infection with the homologous type. We conclude that no species-specific protection can be achieved against intraperitoneal Streptococcus pneumoniae infection with optimally capsulated bacteria in outbred mice by passive immunization with antibodies to C-Ps.
在小鼠模型中检测了抗C多糖（C-Ps）抗体预防实验性肺炎球菌感染的能力。无论是针对磷酰胆碱（PC）或C-Ps主链的抗C-Ps小鼠单克隆抗体，还是抗C-Ps兔多克隆免疫血清，均未显示出对6A和14型肺炎球菌感染的预防作用。具有PC特异性的单克隆抗体对以PC作为其荚膜多糖一部分的27型肺炎球菌感染具有预防作用。型特异性单克隆和多克隆抗体对同源型感染具有高度预防作用。我们得出结论，在远交系小鼠中，通过用抗C-Ps抗体进行被动免疫，无法对最佳荚膜化细菌引起的腹腔感染实现针对肺炎链球菌的种特异性预防。
