Martin J E, Mather K, Swash M
Department of Neuropathology, Royal London Hospital, Whitechapel, UK.
Neurology. 1993 Jul;43(7):1420-2. doi: 10.1212/wnl.43.7.1420.
Heterotopic neurons in ALS have suggested aberrant neuronal migration during development. We studied 10 cases with ALS, 10 normal controls, and 10 cases with anterior horn cell disease, including spinal muscular atrophy and acute and remote poliomyelitis. There was no excess of heterotopic neurons in ALS compared with either control group and therefore no failure of neuronal migration in ALS.
肌萎缩侧索硬化症（ALS）中的异位神经元提示其在发育过程中存在异常的神经元迁移。我们研究了10例ALS患者、10例正常对照以及10例前角细胞疾病患者，包括脊髓性肌萎缩症、急性和陈旧性脊髓灰质炎。与任一对照组相比，ALS患者中异位神经元并无增多，因此ALS不存在神经元迁移失败的情况。
