Kusenbach G, Friedrichs F, Skopnik H, Heimann G
Department of Pediatrics, Technical University of Aachen, Federal Republic of Germany.
Pediatr Pulmonol. 1993 May;15(5):273-8. doi: 10.1002/ppul.1950150503.
Bicycle ergospirometry was performed on 14 patients with cystic fibrosis (CF), for evaluating the effects of salbutamol and theophylline on the ventilatory response to exercise. After 1 week without bronchodilator therapy the patients cycled at 1/3 and 2/3 of their individual maximal working capacity (Wmax). The test was repeated three times after treatment with salbutamol, theophylline, or both drugs, respectively. After the combined therapy, physiological deadspace, ventilation, ventilatory equivalent of oxygen, and end-expiratory oxygen pressure increased significantly during steady state exercise at 1/3 Wmax. Similar, although not statistically significant changes, were observed after monotherapy with salbutamol or theophylline and during exercise at 2/3 Wmax. These effects could not be predicted by any lung function tests at rest or by the Shwachman-Kulczycki score. The results indicate that in some patients with CF bronchodilators can impair lung function during exercise. In conclusion, the effects of medication on exercise performance of patients with CF have to be considered. Especially, the use of bronchodilators requires a careful evaluation of their real benefit in each individual patient.
对14例囊性纤维化（CF）患者进行了自行车运动肺功能测试，以评估沙丁胺醇和茶碱对运动通气反应的影响。在停止支气管扩张剂治疗1周后，患者以其个人最大工作能力（Wmax）的1/3和2/3进行骑行。分别用沙丁胺醇、茶碱或两种药物治疗后，该测试重复进行三次。联合治疗后，在以1/3 Wmax进行稳态运动期间，生理死腔、通气、氧通气当量和呼气末氧分压显著增加。在使用沙丁胺醇或茶碱单药治疗后以及以2/3 Wmax进行运动期间，观察到了类似的变化，尽管无统计学意义。这些影响无法通过任何静息肺功能测试或Shwachman-Kulczycki评分来预测。结果表明，在一些CF患者中，支气管扩张剂可能会在运动期间损害肺功能。总之，必须考虑药物对CF患者运动表现的影响。特别是，使用支气管扩张剂需要仔细评估其对每个患者的实际益处。
