Theissen P, Kaldewey S, Moka D, Bunke J, Voth E, Schicha H
Klinik und Poliklinik für Nuklearmedizin, Universität zu Kölin, FRG.
Nuklearmedizin. 1993 Jun;32(3):134-9.
31Phosphorus magnetic resonance spectroscopy allows an in vivo examination of energy metabolism. The present study was designed to evaluate whether in patients with latent hyperthyroidism alterations of muscle energy metabolism could be found similar to those observed in patients with overt hyperthyroidism. In 10 patients with overt hyperthyroidism before therapy and 20 with latent hyperthyroidism (also without therapy) and in 24 healthy volunteers magnetic resonance spectroscopy of the calf muscle was performed within a 1.5-Tesla magnet. Muscle concentrations of phosphocreatine, inorganic phosphate, and ATP were quantified compared to an external standard solution of K2HPO4. In the patients with overt hyperthyroidism and with latent hyperthyroidism a significant decrease of phosphocreatine was found. Further, the ATP concentration in patients with latent and manifest hyperthyroidism tended towards lower values. There were no significant differences in the decrease of phosphocreatine and ATP between both patient groups. Therefore, this study for the first time shows that alterations of energy metabolism in latent hyperthyroidism can be measured and that they are similar to those observed in overt hyperthyroidism.
磷磁共振波谱法可对能量代谢进行体内检查。本研究旨在评估在亚临床甲状腺功能亢进患者中，是否能发现与显性甲状腺功能亢进患者类似的肌肉能量代谢改变。对10例未经治疗的显性甲状腺功能亢进患者、20例亚临床甲状腺功能亢进患者（同样未经治疗）以及24名健康志愿者，在1.5特斯拉的磁体中进行小腿肌肉的磁共振波谱检查。将磷酸肌酸、无机磷酸盐和三磷酸腺苷（ATP）的肌肉浓度与K2HPO4外标溶液进行比较定量。在显性甲状腺功能亢进患者和亚临床甲状腺功能亢进患者中，均发现磷酸肌酸显著降低。此外，亚临床和显性甲状腺功能亢进患者的ATP浓度有降低的趋势。两组患者之间磷酸肌酸和ATP降低情况无显著差异。因此，本研究首次表明，亚临床甲状腺功能亢进患者的能量代谢改变可以被检测到，且与显性甲状腺功能亢进患者中观察到的改变相似。
