Effect of amiloride on sodium-calcium exchange activity in rat cardiac myocytes.
作者信息
Antolini M, Trevisi L, Debetto P, Luciani S
机构信息
Department of Pharmacology, University of Padova, Italy.
出版信息
Pharmacol Res. 1993 Apr;27(3):227-31. doi: 10.1006/phrs.1993.1021.
PMID:8327403
Abstract
The effect of amiloride on Na+/Ca2+ exchange activity and adenylate energy charge in isolated rat cardiac myocytes has been studied. Amiloride inhibits Na+/Ca2+ exchange activity in rat cardiac myocytes with an IC50 of 1.76 mM when added to the external side of the cell membrane, whereas it is a weaker inhibitor when present at the cytoplasmic side. The adenylate energy charge in rat cardiac myocytes is unaffected by amiloride.
摘要
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