Hirata M, Takushima M, Kage M, Fukuma T
Department of Parasitology, Kurume University School of Medicine, Japan.
Parasitol Res. 1993;79(4):316-21. doi: 10.1007/BF00932188.
Hepatic, pulmonary, and intestinal granuloma formation was comparatively studied in mice implanted with freshly laid Schistosoma japonicum eggs. The liver and the lung showed similar kinetics of tissue reactivity, with the magnitude in the lung being of a significantly lower degree. When the footpad-swelling test was performed, the delayed-type hypersensitivity (DTH) response during hepatic granuloma formation was found to be significantly increased from the 28th day after egg implantation onward, whereas pulmonary granuloma formation showed a peak response at 14-21 days, suggesting differing kinetics of granulomatous reaction. In histologic analysis, the temporal infiltration of monocytes was revealed to correspond to the increase in the DTH response. During intestinal granuloma formation, eosinophil infiltration was the most marked feature. The present study demonstrates that throughout the course of reaction, cellular components participating in egg-granuloma formation differ greatly according to the tissues involved.
对植入新鲜日本血吸虫卵的小鼠的肝脏、肺和肠道肉芽肿形成进行了比较研究。肝脏和肺表现出相似的组织反应动力学，肺中的反应程度明显较低。进行足垫肿胀试验时，发现肝脏肉芽肿形成过程中的迟发型超敏反应（DTH）从植入虫卵后第28天起显著增强，而肺肉芽肿形成在14 - 21天出现峰值反应，提示肉芽肿反应的动力学不同。组织学分析显示，单核细胞的一过性浸润与DTH反应的增强相对应。在肠道肉芽肿形成过程中，嗜酸性粒细胞浸润是最显著的特征。本研究表明，在整个反应过程中，参与虫卵肉芽肿形成的细胞成分根据受累组织的不同而有很大差异。
