Sergiacomi G, Palma E, Cianciulli P, Forte L, Papa G, Simonetti G
Istituto di Radiologia, Università degli Studi di Roma Tor Vergata, Ospedale S. Eugenio, Roma.
Radiol Med. 1993 May;85(5):570-3.
Fifteen thalassemia intermedia patients were considered, whose clinical and radiological findings were examined and compared. Eight patients underwent regular transfusion therapy. All patients underwent total body CT: the volume of ectopic erythropoiesis foci was calculated by a digital calculation algorithm (ROI volume). This work was aimed at correlating the quantitative measures of ectopic erythropoiesis assessed by CT with serum level of erythropoietin (EPO) and of trasferrin-free receptors (TfR) in both transfused and non-transfused patients, also considering the volume changes of ectopic erythropoiesis and bone changes over 36 months' follow-up. A direct correlation was demonstrated between serum transferrin and ectopic erythropoietic masses in transfusion-dependent patients: in fact, increased values of serum transferrin correspond to the enlargement of these masses and to bone lesion worsening.
研究纳入了15例中间型地中海贫血患者，对其临床和影像学检查结果进行了分析比较。8例患者接受了常规输血治疗。所有患者均接受了全身CT检查：通过数字计算算法（ROI体积）计算异位造血灶的体积。这项研究旨在将CT评估的异位造血定量指标与输血和未输血患者的血清促红细胞生成素（EPO）及转铁蛋白受体（TfR）水平相关联，同时观察36个月随访期内异位造血体积变化和骨骼变化。结果显示，在依赖输血的患者中，血清转铁蛋白与异位造血肿块之间存在直接相关性：事实上，血清转铁蛋白值升高与这些肿块增大及骨骼病变恶化相关。
