Werth B, Kuhn M, Hartmann K, Kobler E, Reinhart W H
Medizinische Klinik, Kantonsspital Chur.
Schweiz Med Wochenschr. 1993 Jun 12;123(23):1203-6.
Drug-induced liver disease can mimic any form of acute or chronic liver disease. Suspected drug-induced liver disease makes up between 4 and 7% of all reports of adverse drug effects voluntarily reported to central registries. We report on all patients with drug-induced hepatotoxic reactions voluntarily reported to the Swiss Adverse Drug Reaction Center from 1989 to 1991. In that period there was a total of 2084 reports of which 140 (6.7%) concerned the liver. In 16 cases two drugs were simultaneously involved, so that 156 investigations were carried out. We found a causal relationship in 123 cases. Antibiotic and chemotherapeutic agents were the drugs most frequently involved. There were seven fatal cases (5%). Our data correspond with the data in the literature. Regarding the amount of drugs prescribed, the hepatic adverse effect can be regarded as common.
药物性肝病可模仿任何形式的急性或慢性肝病。疑似药物性肝病占自愿向中央登记处报告的所有药物不良反应报告的4%至7%。我们报告了1989年至1991年自愿向瑞士药物不良反应中心报告的所有药物性肝毒性反应患者。在此期间，共有2084份报告，其中140份（6.7%）与肝脏有关。在16例病例中，两种药物同时涉及，因此进行了156项调查。我们在123例病例中发现了因果关系。抗生素和化疗药物是最常涉及的药物。有7例死亡病例（5%）。我们的数据与文献中的数据一致。就所开药物的数量而言，肝脏不良反应可被视为常见。
