Gulba D C
Klinikum Rudolf Virchow, Franz-Volhard-Klinik und Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch.
Z Kardiol. 1993;82 Suppl 2:183-5.
Contradicting previous views that reperfusion therapy in acute myocardial infarction has to be restricted to the first 4 to 6 h, the paradigm of thrombolysis in acute myocardial infarction has to be expanded to 12 h, since the results of the LATE study have been published. While early thrombolysis (up to 90 min) aims towards myocardial salvage, the benefit of late reperfusion seems to depend on an improved myocardial remodeling and on rhythmic stabilization (open artery hypothesis). Today the value of late reperfusion therapy can be regarded as proven in a clinical setting, the mechanisms of late reperfusion therapy, however, still remain to be settled.
与之前认为急性心肌梗死再灌注治疗必须限制在发病后的最初4至6小时的观点相反，急性心肌梗死溶栓治疗的范例必须扩展至12小时，因为LATE研究的结果已经公布。早期溶栓（至90分钟）旨在挽救心肌，而晚期再灌注的益处似乎取决于改善心肌重构和节律稳定（开放动脉假说）。如今，晚期再灌注治疗在临床环境中的价值已被视为得到证实，然而，晚期再灌注治疗的机制仍有待确定。
