Aida Y, Takeuchi E, Shinagawa T, Tadokoro M, Inoue S, Omata Y, Noro M
Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
Acta Cytol. 1993 Jul-Aug;37(4):547-51.
Fine needle aspiration (FNA) cytology of lipid-secreting carcinoma of the breast was performed on a 43-year-old woman who was admitted with a left breast tumor. Smears of the aspirate showed atypical cells that contained numerous large and small vacuoles in the cytoplasm and were diagnosed as adenocarcinoma of the breast. A modified radical mastectomy was performed under the diagnosis of breast carcinoma. A solid, yellowish, milky white, well-demarcated tumor was found in the resected specimen. Microscopically, hematoxylin and eosin staining revealed foamy and granular vacuoles in the cytoplasm of the tumor cells similar to those seen on the smears, which were positive for lipid staining. Electron microscopic examination also showed numerous intracytoplasmic lipid droplets in the tumor cells. This tumor was finally diagnosed as lipid-secreting carcinoma of the breast on the basis of histologic and electron microscopic features. Lipid-secreting carcinoma of the breast is rare, and only one recurrent case diagnosed by cytology in pleural and pericardial fluids has been described. Since the tumor cells originating in lipid-secreting carcinoma of the breast differ from ordinary breast carcinoma cells, FNA cytology is useful in diagnosing this neoplasm.
对一名因左乳肿瘤入院的43岁女性进行了乳腺脂质分泌癌的细针穿刺（FNA）细胞学检查。抽吸物涂片显示非典型细胞，其细胞质中含有大量大小不一的空泡，诊断为乳腺腺癌。在乳腺癌诊断下进行了改良根治性乳房切除术。在切除标本中发现一个实性、淡黄色、乳白色、边界清晰的肿瘤。显微镜下，苏木精和伊红染色显示肿瘤细胞的细胞质中有泡沫状和颗粒状空泡，与涂片所见相似，脂质染色呈阳性。电子显微镜检查也显示肿瘤细胞中有大量胞质内脂质滴。根据组织学和电子显微镜特征，该肿瘤最终诊断为乳腺脂质分泌癌。乳腺脂质分泌癌罕见，仅描述过1例通过胸膜和心包液细胞学诊断的复发病例。由于起源于乳腺脂质分泌癌的肿瘤细胞与普通乳腺癌细胞不同，FNA细胞学在诊断这种肿瘤方面很有用。
