Kurebayashi J, Izuo M, Ishida T, Kurosumi M, Kawai T
Second Department of Surgery, Gunma University School of Medicine.
Jpn J Clin Oncol. 1988 Sep;18(3):249-54.
Two very rare cases of lipid-secreting carcinoma of the breast are reported, together with a review of the literature. Both patients were Japanese women aged 70 and 81 years, respectively. In each, a mass had been found in the breast, and radical mastectomies were performed based on a diagnosis of breast cancer at an early clinical stage. Both resected tumors were found to be solid and localized. In them, both estrogen and progesterone receptors were negative. Microscopically, hematoxylin-eosin staining showed the tumor cells to have foamy and vacuolated eosinophilic cytoplasm. Lipid staining showed the vesicles in the cytoplasm of the tumor cells to be colored a flaming red and consequently recognized as lipid droplets. An electron-microscopic study showed that the tumor cells contained various sizes of lipid droplets in the cytoplasm with no degenerative changes, and suggested that these lipid droplets were produced and stored in the tumor cells. It would appear, from the literature that lipid-secreting carcinomas have aggressive clinical courses, but neither vascular invasion nor lymph node metastasis was seen in either of our two cases.
本文报告了两例极为罕见的乳腺脂质分泌癌，并对相关文献进行了综述。两位患者均为日本女性，年龄分别为70岁和81岁。每位患者均在乳腺中发现肿块，并在临床早期诊断为乳腺癌后进行了根治性乳房切除术。切除的肿瘤均为实性且局限。两者的雌激素和孕激素受体均为阴性。显微镜下，苏木精-伊红染色显示肿瘤细胞具有泡沫状和空泡状嗜酸性细胞质。脂质染色显示肿瘤细胞胞质内的小泡呈火焰红色，因此被识别为脂滴。电子显微镜研究表明，肿瘤细胞胞质内含有各种大小的脂滴，无退行性改变，提示这些脂滴是在肿瘤细胞内产生和储存的。从文献来看，脂质分泌癌具有侵袭性临床病程，但我们这两例患者均未出现血管侵犯或淋巴结转移。
