Neuroleptic malignant syndrome induced by nemonapride.

A 17-year-old girl with acute schizophrenic symptoms who after the administration of 9 mg P.O. of nemonapride, developed a neuroleptic malignant syndrome, a rare but serious adverse effect of neuroleptic medication, is reported. She recovered after the administration of dantrolene. This side effect induced by nemonapride has not been reported previously. Nemonapride is a highly selective dopamine D-2 antagonist, equivalent to haloperidol. It is supposed that nemonapride can induce the neuroleptic malignant syndrome similar to haloperidol.