Joseph G, Hadley T, Djulbegovic B, Hamm J, Seeger J, Blumenreich M, Woodcock T
Division of Medical Oncology, University of Louisville School of Medicine, Kentucky.
Am J Clin Oncol. 1993 Aug;16(4):319-22. doi: 10.1097/00000421-199308000-00008.
Twenty patients with relapsed or refractory non-Hodgkin's lymphoma were treated with high-dose chlorambucil (14 mg/m2 every 6 hours for 6 doses) and dexamethasone (40 mg/day for 5 days). There was a 45% response rate with 17% complete responses. The median duration of complete response was 7 months. The regimen was well tolerated and had minimal toxicity.
20例复发或难治性非霍奇金淋巴瘤患者接受了大剂量苯丁酸氮芥（每6小时14mg/m²，共6剂）和地塞米松（40mg/天，共5天）治疗。缓解率为45%，完全缓解率为17%。完全缓解的中位持续时间为7个月。该方案耐受性良好，毒性极小。
