Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents.
作者信息
Richman D D
机构信息
Department of Pathology, University of California, San Diego, La Jolla 92093-0679.
出版信息
Antimicrob Agents Chemother. 1993 Jun;37(6):1207-13. doi: 10.1128/AAC.37.6.1207.
Abstract
摘要
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Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT).HIV-1逆转录酶中的多个突变赋予对齐多夫定（AZT）的高水平耐药性。
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HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.在长期治疗期间分离出的对齐多夫定（AZT）敏感性降低的HIV。
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