子宫内膜异位症患者会产生抗子宫内膜自身抗体。
Antiendometrial autoantibodies are generated in patients with endometriosis.
作者信息
Gorai I, Ishikawa M, Onose R, Hirahara F, Minaguchi H
机构信息
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan.
出版信息
Am J Reprod Immunol. 1993 Mar;29(2):116-23. doi: 10.1111/j.1600-0897.1993.tb00575.x.
PROBLEM
Our aim was to investigate endometrial antigens involved in the autoimmunity of endometriosis.
METHOD
We detected endometrial antigens against which autoantibodies directed with Western blotting.
RESULTS
Thirteen (72.2%), 14 (77.8%), and 15 (83.3%) of 18 serum samples from endometriosis patients had antibodies reactive against endometrial antigen wtih MW of 26 kd, 34 kd, and 42 kd, respectively, while 6 (33.3%), 8 (44.4%), and 8 (44.4%) of 18 samples from normal control women reacted against these antigens, respectively. The frequencies of antibodies to the endometrial antigens were significantly (P < 0.05) higher in the endometriosis patients than in the normal control women. Antibodies in peritoneal fluid (PF) reacted against antigens with MW of 26, 34, 38, 42, and 64 kd, while those from the normal control reacted against antigens with MW of 38, 42, and 64 kd. Serum samples from normal fertile males did not show any reactivity against these endometrial antigens.
CONCLUSIONS
Our results show that autoantibodies reactive against endometrial antigens are present in patients with endometriosis.
问题
我们的目的是研究参与子宫内膜异位症自身免疫的子宫内膜抗原。
方法
我们用蛋白质印迹法检测了能产生自身抗体的子宫内膜抗原。
结果
来自子宫内膜异位症患者的18份血清样本中，分别有13份（72.2%）、14份（77.8%）和15份（83.3%）具有针对分子量为26kd、34kd和42kd的子宫内膜抗原的反应性抗体，而来自正常对照女性的18份样本中，分别有6份（33.3%）、8份（44.4%）和8份（44.4%）对这些抗原产生反应。子宫内膜异位症患者中针对子宫内膜抗原的抗体频率显著高于正常对照女性（P<0.05）。腹腔液（PF）中的抗体与分子量为26、34、38、42和64kd的抗原发生反应，而正常对照的腹腔液抗体与分子量为38、42和64kd的抗原发生反应。正常生育男性的血清样本对这些子宫内膜抗原未显示任何反应性。
结论
我们的结果表明，子宫内膜异位症患者体内存在针对子宫内膜抗原的自身抗体。
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