Aloamaka C P, Ezimokhai M, Cherian T, Morrison J
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, UAE University, Al Ain.
Exp Physiol. 1993 May;78(3):403-10. doi: 10.1113/expphysiol.1993.sp003694.
The role of endothelium in the decreased contraction to phenylephrine in aorta of pregnant Wistar rats has been studied. Contractions in response to phenylephrine were significantly decreased in aortic rings from pregnant rats compared to those from non-pregnant rats. Pretreatment of the rings with indomethacin did not significantly alter the pattern of responses. When endothelium was removed from the rings, contractions of rings from non-pregnant rats were similar to those from pregnant rats. Acetylcholine-induced relaxations of rings from pregnant and non-pregnant rats precontracted with phenylephrine were not significantly different. The results suggest that in the rat aorta and under in vitro conditions, pregnancy-induced attenuation of contraction to phenylephrine is, at least partly, endothelium dependent and that the release of the endothelium factor responsible for this alteration in response may be indomethacin insensitive.
研究了内皮在妊娠Wistar大鼠主动脉对去氧肾上腺素收缩反应降低中的作用。与未妊娠大鼠相比，妊娠大鼠主动脉环对去氧肾上腺素的收缩反应显著降低。用吲哚美辛预处理环并未显著改变反应模式。当从环中去除内皮时，未妊娠大鼠环的收缩与妊娠大鼠的相似。用去氧肾上腺素预收缩的妊娠和未妊娠大鼠环对乙酰胆碱诱导的舒张没有显著差异。结果表明，在大鼠主动脉和体外条件下，妊娠引起的对去氧肾上腺素收缩反应的减弱至少部分是内皮依赖性的，并且负责这种反应改变的内皮因子的释放可能对吲哚美辛不敏感。
