Maffioli L S, Mascheroni L, Clemente C, Baldini M, Castellani M R
Division of Nuclear Medicine, Istituto Nazionale per lo Studio, la Cura dei Tumori, Milan, Italy.
J Nucl Biol Med (1991). 1993 Mar;37(1):18-20.
In this report we describe our experience with [123I]IBZM ([123I]-(S)-2-hydroxy-3-iodo-6-methoxy-N-[(1-ethyl-2-pyrrolid inyl)methyl] benzamide), used to image the lesions in a female patient affected by metastatic melanoma. Marked uptake of [123I]IBZM in an area corresponding to a palpable lymph-nodal mass was observed in images collected 2 and 5 hours after i.v. tracer administration. Tumour to non-tumour ratios evaluated on planar maps were found to be 2.04 and 2.35, respectively. Surgical excision and histological examination of inguinal nodes confirmed the presence of melanoma lymph-nodal metastases. Although scintigraphy with radiolabelled [123I]IBZM is widely used for neuro-psychiatric disorders, we have found no reports in the literature of any application of this tracer in oncology. Even if the biological bases underlying the findings reported here remain unclear (although they are probably related to the neural crest origin of the melanocytes), the quality of imaging found suggests that this tracer may provide a new diagnostic tool for the imaging of melanoma tumours.
在本报告中，我们描述了使用[123I]IBZM（[123I]-(S)-2-羟基-3-碘-6-甲氧基-N-[(1-乙基-2-吡咯烷基)甲基]苯甲酰胺）对一名转移性黑色素瘤女性患者的病灶进行成像的经验。在静脉注射示踪剂后2小时和5小时采集的图像中，观察到[123I]IBZM在与可触及的淋巴结肿块相对应的区域有明显摄取。在平面图像上评估的肿瘤与非肿瘤比值分别为2.04和2.35。腹股沟淋巴结的手术切除和组织学检查证实存在黑色素瘤淋巴结转移。尽管放射性标记的[123I]IBZM闪烁扫描广泛用于神经精神疾病，但我们在文献中未发现该示踪剂在肿瘤学中应用的任何报道。即使此处报告结果的生物学基础尚不清楚（尽管它们可能与黑素细胞的神经嵴起源有关），所发现的成像质量表明该示踪剂可能为黑色素瘤肿瘤成像提供一种新的诊断工具。
