Lefaix J L, Martin M, Tricaud Y, Daburon F
Laboratoire de Radiobiologie Appliquée, Commissariat à L'Energie Atomique-CEN Saclay, Gif sur Yvette, France.
Br J Radiol. 1993 Jun;66(786):537-44. doi: 10.1259/0007-1285-66-786-537.
Localized irradiation of the skin and subcutaneous tissues with large single doses of gamma-rays can induce delayed effects characterized by fibrosis which invades the irradiated tissues. In this study the depth of penetration of muscle fibrosis was measured in the pig 30 weeks after irradiation of the skin surface with single doses of 192Ir gamma-rays of 16-256 Gy. Irradiation was directed either to the outer side of the thigh or to the back, close to the mid-dorsal line. Fibrosis only developed in irradiated muscle after doses that induced moist desquamation of the skin in the acute phase of the reaction, i.e. after skin surface doses of 48-64 Gy. In skeletal muscles, the limit of fibrotic expansion was reached at a depth dose of 14 +/- 4 Gy (+/- SD) for skin surface doses exceeding 48 Gy.
用大剂量单次γ射线对皮肤和皮下组织进行局部照射，可诱发以纤维化侵入受照组织为特征的迟发效应。在本研究中，用16 - 256 Gy的192Irγ射线单次照射猪的皮肤表面30周后，测量了肌肉纤维化的穿透深度。照射部位为大腿外侧或靠近背中线的背部。只有在反应急性期引起皮肤湿性脱屑的剂量（即皮肤表面剂量为48 - 64 Gy）照射后，受照肌肉才会出现纤维化。在骨骼肌中，当皮肤表面剂量超过48 Gy时，纤维化扩展的深度剂量极限为14±4 Gy（±标准差）。
