Sullivan H C, Harik S I
Department of Neurology, University Hospitals of Cleveland, OH 44106.
Brain Res. 1993 May 28;612(1-2):336-8. doi: 10.1016/0006-8993(93)91682-i.
We used [3H]glibenclamide binding to assess ATP-sensitive K+ channels in isolated cerebral microvessels and in the cerebral cortex of the rat. We found no measurable specific glibenclamide binding in cerebral microvessels despite its abundance in cerebral cortical membranes, implying that ATP-sensitive K+ channels are not present in cerebral microvessels.
我们使用[3H]格列本脲结合法来评估大鼠离体脑微血管和大脑皮质中的ATP敏感性钾通道。尽管格列本脲在大脑皮质膜中含量丰富，但我们在脑微血管中未检测到可测量的特异性格列本脲结合，这意味着脑微血管中不存在ATP敏感性钾通道。
