Ardisia C, Venti G, Colozza M A, Breschi C, Porfirio B, Davis S, Tonato M, Donti E
Istituto di Clinica Medica I, Università di Perugia, Italy.
Cancer Genet Cytogenet. 1993 Jun;67(2):113-6. doi: 10.1016/0165-4608(93)90162-f.
The expression of fragile sites induced by aphidicolin (APC) was evaluated on metaphase chromosomes obtained from the peripheral blood lymphocytes of 26 women with breast cancer and 15 sex- and age-matched normal controls. Both the proportion of damaged cells (P < 0.001) and the mean number of gaps and breaks per cell (0.02 < P < 0.05) were significantly higher in the patient group. There were no differences in either the age-related fragile site levels or the expression of single fragile sites between patients and controls. Our findings indicate an increased genetic instability in women with breast carcinoma.
对26名乳腺癌女性患者及15名年龄和性别匹配的正常对照者外周血淋巴细胞中期染色体上由阿非科林（APC）诱导的脆性位点表达进行了评估。患者组中受损细胞比例（P < 0.001）以及每个细胞的间隙和断裂平均数（0.02 < P < 0.05）均显著更高。患者与对照者在年龄相关脆性位点水平或单个脆性位点的表达方面均无差异。我们的研究结果表明乳腺癌女性患者的遗传不稳定性增加。
