Devadoss P O, Klegerman M E, Groves M J
Institute for Tuberculosis Research, College of Pharmacy, University of Illinois, Chicago.
Cytobios. 1993;74(296):49-58.
Instillation of BCG vaccine directly into the bladder of patients suffering from superficial bladder tumours represents the major clinical application of this material. The mode of action is by no means clearly defined but it is known that the BCG cells need to be in close proximity to the tumours and may be capable of directly targeting the tumour cells through a fibronectin/fibronectin receptor interaction. In addition to cellular adherence there is a local stimulation of macrophages which is known to phagocytose mycobacteria. Use of a murine S180 sarcoma model facilitated the quantitative measurement of antitumour activity of BCG and BCG isolates. Ultrastructural examination of the BCG/sarcoma interaction confirmed that, in fact, these tumour cells do phagocytose and subsequently kill the BCG cells. The relationship between this phenomenon and the subsequent tumour cell death is not currently clear, although a strong tumoricidal agent has recently been isolated from BCG cells.
将卡介苗直接注入患有浅表性膀胱肿瘤的患者膀胱是这种物质的主要临床应用。其作用方式尚未明确界定，但已知卡介苗细胞需要与肿瘤紧密相邻，并且可能能够通过纤连蛋白/纤连蛋白受体相互作用直接靶向肿瘤细胞。除了细胞黏附外，还会对巨噬细胞产生局部刺激，已知巨噬细胞会吞噬分枝杆菌。使用小鼠S180肉瘤模型有助于定量测量卡介苗和卡介苗分离株的抗肿瘤活性。对卡介苗/肉瘤相互作用的超微结构检查证实，实际上这些肿瘤细胞确实会吞噬并随后杀死卡介苗细胞。尽管最近已从卡介苗细胞中分离出一种强大的杀肿瘤剂，但目前尚不清楚这种现象与随后肿瘤细胞死亡之间的关系。
