Micheli F, Lehkuniec E, Gatto M, Pelli M, Asconape J
Department of Neurology, Jose de San Martin University Hospital, Buenos Aires, Argentina.
Funct Neurol. 1993 Mar-Apr;8(2):103-7.
A 13-year-old girl developed left partial motor status epilepticus with severe postictal hemiparesis. Magnetic resonance imaging showed a right frontoparietal hyperintense T2 weighted signal. Treated with phenytoin, carbamazepine and phenobarbital, seizures subsided but left choreic-like flinging movements, consistent with hemiballism, presented 2 days later. On phenytoin withdrawal, symptoms gradually remitted with mild residual dystonia at 14 months follow-up. It is speculated that the lesion might have rendered the cortex more susceptible to phenytoin, inducing unilateral toxicity.
一名13岁女孩出现左侧部分运动性癫痫持续状态，并伴有严重的发作后偏瘫。磁共振成像显示右侧额顶叶T2加权信号增强。使用苯妥英钠、卡马西平和苯巴比妥治疗后，癫痫发作得到缓解，但2天后出现了与偏身投掷症相符的左侧舞蹈样投掷运动。停用苯妥英钠后，症状逐渐缓解，在14个月的随访中仍有轻度残留肌张力障碍。据推测，病变可能使皮质对苯妥英钠更敏感，从而诱发单侧毒性。
