Lockemann U, Pueschel K
Institute for Legal Medicine, University of Hamburg, Germany.
Forensic Sci Int. 1993 May;59(2):169-75. doi: 10.1016/0379-0738(93)90156-5.
According to literature, siderophages are a characteristic histological finding in the lung of deceased drug addicts (IVDA). It was the aim of our study to evaluate their pathognomonic significance. The lungs of 591 drug deaths in Hamburg were examined histologically for siderophages in two series, with different 'Berlinerblau' (Prussian blue) staining methods. The first series (investigation period 1980-1990) showed iron-containing macrophages in 36 of 420 drug deaths (8.6%) compared with a control-group (healthy young persons dying from unnatural causes of death) in which only one was positive (2%). In a second series, using a more sensitive staining method, 80 of 171 drug deaths (47%) in the year 1991 showed siderophages, whilst in a control-group, 17 of 35 cases (49%) were positive. According to our findings the pathognomonic value of siderophages in the lung of IVDA is doubtful. There is a need for further histochemical and ultrastructural investigations concerning the morphology and etiology of pulmonary macrophages in IVDA.
据文献记载，含铁小体是已故吸毒者（静脉注射吸毒者）肺部的一种特征性组织学表现。我们研究的目的是评估其病理诊断意义。采用不同的“柏林蓝”（普鲁士蓝）染色方法，对汉堡591例吸毒死亡者的肺部进行了两个系列的组织学检查，以寻找含铁小体。第一个系列（研究期为1980 - 1990年）显示，420例吸毒死亡者中有36例（8.6%）存在含铁巨噬细胞，而对照组（因非自然死因死亡的健康年轻人）中只有1例呈阳性（2%）。在第二个系列中，采用更敏感的染色方法，1991年171例吸毒死亡者中有80例（47%）显示有含铁小体，而对照组35例中有17例（49%）呈阳性。根据我们的研究结果，含铁小体在静脉注射吸毒者肺部的病理诊断价值值得怀疑。有必要对静脉注射吸毒者肺部巨噬细胞的形态和病因进行进一步的组织化学和超微结构研究。
