Herrmann W M, Hiersemenzel R, Aigner M, Lobisch M, Riethmüller-Winzen H, Michel I
Psychiatrische Klinik und Poliklinik, Klinikum Rudolf Virchow, Freie Universität Berlin.
Fortschr Med. 1993 May 30;111(15):266-70.
To answer the question as to whether the analgesic flupirtine is suitable for long-term treatment of chronic pain, its side effects and efficacy were investigated over a 12-month treatment period. A total of 191 patients with chronic pain of degenerative and/or inflammatory musculoskeletal diseases were admitted to the open, uncontrolled multicenter study. This was followed by a single-blind placebo follow-up period of two weeks aimed at detecting withdrawal phenomena as a sign of a possible addictive potential of flupirtine.
On the basis of patient and investigator documentation, laboratory studies and clinical examinations, flupirtine was found to be both well tolerated and effective. No signs of tolerance, addiction or relevant interactions were observed. The side effect profile differed from that of the opioids or prostaglandin synthesis inhibitors (NSAIDs).
为了回答镇痛药氟吡汀是否适用于慢性疼痛的长期治疗这一问题，在为期12个月的治疗期间对其副作用和疗效进行了研究。共有191例患有退行性和/或炎性肌肉骨骼疾病慢性疼痛的患者被纳入这项开放、非对照的多中心研究。随后是为期两周的单盲安慰剂随访期，旨在检测戒断现象，作为氟吡汀可能具有成瘾潜力的迹象。
根据患者和研究者记录、实验室研究及临床检查，发现氟吡汀耐受性良好且有效。未观察到耐受性、成瘾或相关相互作用的迹象。其副作用情况与阿片类药物或前列腺素合成抑制剂（非甾体抗炎药）不同。
