Lüben V, Müller H, Lobisch M, Wörz R
Funktionsbereich Schmerztherapie am Klinikum der Universität Giessen.
Fortschr Med. 1994 Jul 10;112(19):282-6.
In a multicentric double-blind trial, flupirtine was compared with tramadol in the treatment of cancer pain.
Over a period of four weeks, 4 (-6) capsules containing either 100 mg flupirtine (n = 35) or 50 mg tramadol (n = 36) were taken daily in accordance with a fixed time schedule. Severity of pain was scored on a weekly basis using a five-stage verbal scale.
Initially comparable in the two groups, pain was more markedly reduced after four weeks of treatment with flupirtine than after tramadol, the need for additional analgesic drugs also being less in the flupirtine group. The final general assessment by the attending doctors of the results achieved was "good" to "very good" in 63% of the patients on flupirtine, and in 46% of those on tramadol. Undesired effects were observed in 6% of the flupirtine patients and in 19% of those taking tramadol.
在一项多中心双盲试验中，对氟吡汀和曲马多治疗癌痛的效果进行了比较。
在四周的时间里，按照固定时间表，每日服用4（-6）粒胶囊，其中含100毫克氟吡汀（n = 35）或50毫克曲马多（n = 36）。每周使用五阶段言语量表对疼痛严重程度进行评分。
两组最初情况相当，但用氟吡汀治疗四周后疼痛减轻比曲马多更显著，氟吡汀组对额外镇痛药的需求也更少。主治医生对所取得结果的最终总体评估显示，服用氟吡汀的患者中有63%结果为“良好”至“非常好”，服用曲马多的患者中这一比例为46%。6%服用氟吡汀的患者和19%服用曲马多的患者出现了不良反应。
