生长激素及胰岛素样生长因子I和II对大鼠骨骼肌谷氨酰胺代谢的体外影响。
The effects of growth hormone and insulin-like growth factors I and II on glutamine metabolism by skeletal muscle of the rat in vitro.
作者信息
Parry-Billings M, Bevan S J, Opara E, Liu C T, Dunger D B, Newsholme E A
机构信息
Department of Biochemistry, University of Oxford, United Kingdom.
出版信息
Horm Metab Res. 1993 May;25(5):243-5. doi: 10.1055/s-2007-1002087.
Soleus muscle preparations of the rat were incubated in the presence of growth hormone, IGF-I or IGF-II. Growth hormone (10 and 100 ng/ml) increased, but IGF-I and IGF-II were without effect on the concentration of glutamine in soleus muscle. Growth hormone was without effect on the rate of release of glutamine from muscle. In contrast, the rate of release of glutamine was decreased in the presence of IGF-I (750 ng/ml) and increased in the presence of IGF-II (250 and 750 ng/ml). Growth hormone and the IGFs may therefore play an important role in the control of glutamine metabolism by skeletal muscle.
将大鼠的比目鱼肌制剂在生长激素、胰岛素样生长因子-I（IGF-I）或胰岛素样生长因子-II（IGF-II）存在的情况下进行孵育。生长激素（10和100纳克/毫升）可增加比目鱼肌中谷氨酰胺的浓度，但IGF-I和IGF-II对此无影响。生长激素对肌肉中谷氨酰胺的释放速率没有影响。相比之下，在IGF-I（750纳克/毫升）存在的情况下，谷氨酰胺的释放速率降低，而在IGF-II（250和750纳克/毫升）存在的情况下，谷氨酰胺的释放速率增加。因此，生长激素和胰岛素样生长因子可能在骨骼肌对谷氨酰胺代谢的控制中发挥重要作用。
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