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[钙拮抗剂、钾通道开放剂治疗充血性心力衰竭患者]

[Ca-antagonist, K-channel-opener in the treatment of patients with congestive heart failure].

作者信息

Satoh K

机构信息

Department of Pharmacology, Faculty of Medicine, Tottori University.

出版信息

Nihon Rinsho. 1993 May;51(5):1293-8.

PMID:8331797
Abstract

The development of vasodilator drugs that open the K+ channels in blood vessels has been of great academic and practical interest. The K-channel openers (cromakalim, pinacidil and nicorandil) decreased afterload or preload due to their vasodilator action. In addition, K-channel openers produced a cardioprotective effect in lower doses that did not affect coronary blood flow or blood pressure. It is highly expected to be useful for treatment of congestive heart failure.

摘要

开发能打开血管中钾通道的血管扩张药物具有重大的学术和实际意义。钾通道开放剂（色满卡林、匹那地尔和尼可地尔）因其血管扩张作用而降低后负荷或前负荷。此外，钾通道开放剂在不影响冠状动脉血流或血压的较低剂量下产生心脏保护作用。人们高度期望它对治疗充血性心力衰竭有用。

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[Ca-antagonist, K-channel-opener in the treatment of patients with congestive heart failure].[钙拮抗剂、钾通道开放剂治疗充血性心力衰竭患者]
Nihon Rinsho. 1993 May;51(5):1293-8.
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