Dana B, Ellman L, Carvalho A, Daggett W M
J Cardiovasc Surg (Torino). 1977 Jan-Feb;18(1):29-34.
Patients with mitral and aortic valvular stenosis had plasma heparin neutralizing activity (HNA) which were comparable to the control group. In contrast, plasma HNA was elevated in patients with prosthetic valves, particularly in the group with prosthetic aortic valves. Neither the type nor the size of the valve appeared to influence the HNA level. No correlation was evident between plasma HNA levels and a history of systemic arterial embolism. It remains to be determined whether elevated plasma HNA levels result from platelet aggregation on the valve surface, or from platelet lysis due to turbulence around the prosthetic valve.
二尖瓣和主动脉瓣狭窄患者的血浆肝素中和活性（HNA）与对照组相当。相比之下，人工瓣膜患者的血浆HNA升高，尤其是人工主动脉瓣组。瓣膜的类型和大小似乎均不影响HNA水平。血浆HNA水平与体循环动脉栓塞病史之间无明显相关性。血浆HNA水平升高是由于血小板在瓣膜表面聚集，还是由于人工瓣膜周围的湍流导致血小板溶解，仍有待确定。
