Sawatani S, Mandell G, Kiso I, Kantrowitz A
J Cardiovasc Surg (Torino). 1977 Jan-Feb;18(1):63-70.
Tissue molds consisting of polyester mesh jackets covering silicone mandrils were implanted subcutaneously in dogs. When a sufficiently strong layer of connective tissue had formed around the molds they were excised and the mandrils removed. The process of tissue formation was observed and recorded. The forms were used as grafts in either the abdominal aorta or the femoral artery of the dog. Six grafts 10 mm inner diameter, six grafts 6 mm inner diameter and 26 grafts 3 mm inner diameter were implanted. After 4.5 months 80% of the 10 mm grafts, 83% of the 6 mm grafts, but only 4% of the 3 mm grafts remained patent. Histological studies at various intervals after grafting revealed gradual thickening of the neointima. The reason for graft failure was thrombus formation originating at the line of anastomosis.
由覆盖硅酮芯棒的聚酯网套组成的组织模具被皮下植入狗体内。当在模具周围形成足够厚的结缔组织层时，将它们切除并取出芯棒。观察并记录组织形成过程。这些模具被用作狗的腹主动脉或股动脉的移植物。植入了六个内径为10毫米的移植物、六个内径为6毫米的移植物和二十六个内径为3毫米的移植物。4.5个月后，10毫米移植物的80%、6毫米移植物的83%仍保持通畅，但3毫米移植物只有4%保持通畅。移植后不同时间间隔的组织学研究显示新生内膜逐渐增厚。移植物失败的原因是血栓形成于吻合线处。
