重症肌无力免疫球蛋白G对突触后膜乙酰胆碱受体降解的影响。

Effect of myasthenic IgG on degradation of junctional acetylcholine receptor.

作者信息

Takeo G, Motomura M, Mats H, Ohishi K, Yoshimura T, Tsujihata M, Nagataki S

机构信息

First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.

出版信息

Muscle Nerve. 1993 Aug;16(8):840-8. doi: 10.1002/mus.880160807.

DOI:10.1002/mus.880160807

PMID:8332137

Abstract

We investigated the effect of the IgG from patients with myasthenia gravis (MG) on the degradation of normal rat junctional acetylcholine receptor (AChR) labeled with 125I-alpha-bungarotoxin (BuTx) and calculated the degradation rate (DR). The DR for the IgG from these patients was significantly higher than that from healthy volunteers and patients with other autoimmune diseases. For MG, DR was significantly correlated with the severity of the disease but not with anti-AChR antibody titer. DR was accelerated by IgG from patients with generalized MG whose antibody titers were in the normal range and by IgG from patients with ocular MG. These results indicate that measurement of the DR of junctional AChR in normal rats is more closely correlated with the severity of the disease than is measurement of anti-AChR antibody and that the former is a sensitive and confirmatory method for evaluating MG.

摘要

我们研究了重症肌无力（MG）患者的免疫球蛋白G（IgG）对用125I-α-银环蛇毒素（BuTx）标记的正常大鼠接头型乙酰胆碱受体（AChR）降解的影响，并计算了降解率（DR）。这些患者的IgG的DR显著高于健康志愿者和其他自身免疫性疾病患者的DR。对于MG，DR与疾病严重程度显著相关，但与抗AChR抗体滴度无关。全身型MG且抗体滴度在正常范围内的患者的IgG以及眼肌型MG患者的IgG均可加速DR。这些结果表明，正常大鼠接头型AChR的DR测定与疾病严重程度的相关性比抗AChR抗体测定更密切，并且前者是评估MG的一种敏感且具有确证性的方法。