Role of colposcopy in the examination of diethylstilbestrol-exposed women.

Both epithelial and structural abnormalities of the lower genital tract are known to occur in women exposed in utero to DES with greater frequency than in the general population. These changes are usually easily identified by pelvic and colposcopic examination. In general, no treatment is suggested for benign changes. DES-exposed women, however, must be carefully followed-up because of the potential, although rare, of the development of clear cell adenocarcinoma and the increased incidence of squamous intraepithelial neoplasia. With rare exception, screening at yearly intervals is sufficient.