Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, Giri J G, Dower S K, Sims J E, Mantovani A
Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Science. 1993 Jul 23;261(5120):472-5. doi: 10.1126/science.8332913.
Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using monoclonal antibodies, IL-1 prolonged the in vitro survival of polymorphonuclear cells (PMN) through IL-1R I, and IL-4 antagonized the action of IL-1 by inducing expression and release of IL-1R II. Dexamethasone also induced expression and release of the IL-1R II in PMN. These results, together with the effect of antibodies to IL-1R on IL-1-induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1. The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action.
白细胞介素-1（IL-1）通过两种结合分子与细胞相互作用，即I型白细胞介素-1受体（IL-1R I）和II型白细胞介素-1受体（IL-1R II）。IL-1R II的功能尚不清楚。在使用单克隆抗体的研究中，IL-1通过IL-1R I延长了多形核细胞（PMN）的体外存活时间，而IL-4通过诱导IL-1R II的表达和释放拮抗了IL-1的作用。地塞米松也诱导PMN中IL-1R II的表达和释放。这些结果，连同抗IL-1R抗体对单核细胞中IL-1诱导的细胞因子产生的影响，表明IL-1通过IL-1R I作用于骨髓单核细胞，并且IL-1R II通过作为IL-1的诱饵靶点来抑制IL-1的活性。多种调节途径的存在强调了对IL-1作用进行严格控制的必要性。
