Widner H
Department of Neurology, University Hospital, Lund, Sweden.
Acta Neurol Scand Suppl. 1993;146:43-5.
Intracerebral transplantation of immature neural tissue is a promising therapeutical approach that has the potential of restoring damaged neuronal circuitries and reversing functional deficits. The development of the technique as a human application has progressed the furthest in Parkinson's disease (PD), with the demonstration of significant longlasting functional improvements, in combination with evidence of surviving grafted tissue, using a fluorodopa positron emission tomography (PET) scanning technique in a few patients. Although the technique is promising, and the effects observed are significant and of clinical importance for the grafted patients in the best cases so far, there are still incomplete effects and no transplantation treatment is suggested since there are still several technical aspects that might further improve the outcome. The progress of the development in the field is briefly reviewed.
未成熟神经组织的脑内移植是一种很有前景的治疗方法，具有恢复受损神经回路和逆转功能缺陷的潜力。作为一种人类应用技术，该技术在帕金森病（PD）中的发展最为深入，通过氟多巴正电子发射断层扫描（PET）技术，在少数患者中证明了显著的长期功能改善以及移植组织存活的证据。尽管该技术很有前景，且迄今为止在最佳案例中观察到的效果对移植患者具有显著的临床意义，但仍存在不完全的效果，并且由于仍有几个技术方面可能进一步改善结果，因此尚未建议进行移植治疗。本文简要回顾了该领域的发展进程。
