Yang L Y, Chen W P, Lin C Y
Department of Pediatrics, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1993 Jan-Feb;34(1):1-8.
In an attempt to establish the reference data of plasma levels of atrial natriuretic factor (ANF) in different age groups and to evaluate plasma ANF changes before and after hemodialysis (HD) and during continuous ambulatory peritoneal dialysis (CAPD), fifty normal healthy children and 20 children with end-stage renal disease (ESRD) were included. Ten ESRD children received HD and 15 received CAPD therapy. Five cases received HD in the earlier period and then CAPD. The results showed that in normal children, at the age of under one month, there were higher plasma ANF levels. As age increased, plasma ANF levels progressively decreased. During the ESRD before dialysis, there was a significantly increased plasma ANF level (434.1 +/- 80.1 vs 17.5 +/- 2.3 pg/ml, P < 0.0001). Both HD and CAPD reduced the plasma ANF of patients to a lower degree, but the result was still higher than that in normal controls. There were significantly decreased plasma ANF level in the patients with CAPD therapy than those with HD (71.8 +/- 13.7 vs 270.3 +/- 51.9 pg/ml, P < 0.0001). The change of ANF levels was positively correlated with the body weight change and creatinine change after HD.
为了建立不同年龄组血浆心房利钠因子（ANF）水平的参考数据，并评估血液透析（HD）前后及持续性非卧床腹膜透析（CAPD）期间血浆ANF的变化，纳入了50名正常健康儿童和20名终末期肾病（ESRD）儿童。10名ESRD儿童接受HD治疗，15名接受CAPD治疗。5例患者早期接受HD治疗，随后接受CAPD治疗。结果显示，在正常儿童中，1个月以下婴儿的血浆ANF水平较高。随着年龄增长，血浆ANF水平逐渐下降。在ESRD患者透析前，血浆ANF水平显著升高（434.1±80.1对17.5±2.3 pg/ml，P<0.0001）。HD和CAPD均使患者血浆ANF程度降低，但结果仍高于正常对照组。接受CAPD治疗的患者血浆ANF水平显著低于接受HD治疗的患者（71.8±13.7对270.3±51.9 pg/ml，P<0.0001）。HD后ANF水平的变化与体重变化和肌酐变化呈正相关。
