Hakala-Ala-Pietilä T H, Koistinen R A, Salonen R K, Seppälä M T
Department of Obstetrics and Gynecology, Helsinki University Central Hospital.
Am J Obstet Gynecol. 1993 Jul;169(1):35-9. doi: 10.1016/0002-9378(93)90128-6.
The aim was to study the levels of amniotic fluid and maternal serum insulin-like growth factor binding protein-1 levels at 15 to 16 weeks' gestation with regard to fetal growth in the third trimester.
Amniotic fluid (n = 148) and maternal serum (n = 129) levels of insulin-like growth factor binding protein-1 were prospectively measured.
Elevated amniotic fluid insulin-like growth factor binding protein-1 levels were related to fetal growth retardation. At a cutoff value of 3 multiples of the median a high-risk group comprising 16% of all pregnant women was identified. This group included 40% of all small-for-gestational age (birth weight < 10th percentile) and 55% of all very-small-for-gestational-age (birth weight < 5th percentile) infants. Maternal serum insulin-like growth factor binding protein-1 levels were not significantly elevated in these groups.
In most cases of intrauterine growth retardation the disturbance may exist before the condition is detectable by ultrasonography. An elevated amniotic fluid insulin-like growth factor binding protein-1 level may be an early sign.
研究妊娠15至16周时羊水和母血清胰岛素样生长因子结合蛋白-1水平与孕晚期胎儿生长的关系。
前瞻性测量羊水（n = 148）和母血清（n = 129）中胰岛素样生长因子结合蛋白-1的水平。
羊水胰岛素样生长因子结合蛋白-1水平升高与胎儿生长受限有关。在中位数的3倍临界值时，确定了一个占所有孕妇16%的高危组。该组包括所有小于胎龄儿（出生体重<第10百分位数）的40%和所有极低出生体重儿（出生体重<第5百分位数）的55%。这些组中母血清胰岛素样生长因子结合蛋白-1水平未显著升高。
在大多数宫内生长受限病例中，在超声检查可检测到该情况之前可能就已存在干扰。羊水胰岛素样生长因子结合蛋白-1水平升高可能是一个早期迹象。
