[优福啶（UFT）联合顺铂（CDDP）和丝裂霉素（MMC）治疗进展期胃癌。进展期胃癌研究协会]
[UFTPM (UFT + CDDP + MMC) therapy for progressive stomach cancer. Research Association of Progressive Stomach Cancer].
作者信息
Iwazaki R, Yasutake K, Fukuyama Y, Hasegawa K, Koizumi W, Sasai T, Kurihara M, Kubo Y, Ishikawa K, Hayakawa M
机构信息
Dept. of Gastroenterology, Juntendo University School of Medicine.
出版信息
Gan To Kagaku Ryoho. 1993 Jul;20(9):1179-85.
We organized a cooperative research group consisting of 10 institutions and UFTPM therapy was given patients with unresectable and postoperatively relapsed stomach cancer. As the result, 20 cases were registered and the ratio of PR according to the criteria of stomach cancer chemotherapy was 4 out of 17 complete cases (23.5%), excluding 3 incomplete cases. The efficacy for the cases treated with more than 2 courses was 36.4% (4/11) and that for cases with 3 courses was 75% (3/4). One case with 3 courses was resectable and the cancer cells disappeared. Adverse effects of grade 3 or more according to the WHO criteria were observed in 20% of the cases.
我们组织了一个由10个机构组成的合作研究小组，对无法切除及术后复发的胃癌患者进行UFTPM治疗。结果，登记了20例患者，按照胃癌化疗标准，17例完整病例中有4例达到部分缓解（PR）（23.5%），排除3例不完整病例。接受2个疗程以上治疗的病例有效率为36.4%（4/11），接受3个疗程治疗的病例有效率为75%（3/4）。1例接受3个疗程治疗的患者肿瘤可切除且癌细胞消失。按照世界卫生组织标准，20%的病例出现3级或以上不良反应。
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