晚期心力衰竭患者甲状腺激素代谢异常的患病率及临床意义

Prevalence and clinical implications of abnormal thyroid hormone metabolism in advanced heart failure.

作者信息

Hamilton M A

机构信息

Division of Cardiology, University of California, Los Angeles School of Medicine 90024-1679.

出版信息

Ann Thorac Surg. 1993 Jul;56(1 Suppl):S48-52; discussion S52-3. doi: 10.1016/0003-4975(93)90554-u.

DOI:10.1016/0003-4975(93)90554-u

PMID:8333797

Abstract

Patients with advanced congestive heart failure are often severely ill and may experience substantial abnormalities in thyroid hormone metabolism. Thus, we examined this patient population to determine the prevalence and prognostic significance of altered thyroid hormone concentrations, the course of thyroid abnormalities in congestive heart failure survivors, and the potential relationship of thyroid abnormalities to overall metabolic rate. Our results indicate that thyroid hormone metabolism (ie, the triiodothyronine to reverse triiodothyronine ratio) is altered in a majority of patients with advanced congestive heart failure and is an independent predictor of mortality. Currently a study is underway that will provide further evidence for the mechanisms involved in congestive heart failure and abnormal thyroid hormone metabolism.

摘要

晚期充血性心力衰竭患者通常病情严重，甲状腺激素代谢可能出现显著异常。因此，我们对这一患者群体进行了研究，以确定甲状腺激素浓度改变的患病率和预后意义、充血性心力衰竭幸存者甲状腺异常的病程，以及甲状腺异常与总体代谢率之间的潜在关系。我们的结果表明，大多数晚期充血性心力衰竭患者的甲状腺激素代谢（即三碘甲状腺原氨酸与反三碘甲状腺原氨酸的比值）发生改变，并且是死亡率的独立预测指标。目前正在进行一项研究，将为充血性心力衰竭和异常甲状腺激素代谢所涉及的机制提供进一步证据。