自发性和诱发性充血性心力衰竭犬的甲状腺功能
Thyroid function in dogs with spontaneous and induced congestive heart failure.
作者信息
Panciera D L, Refsal K R
机构信息
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706-1102.
出版信息
Can J Vet Res. 1994 Jul;58(3):157-62.
The effects of spontaneous and experimentally induced congestive heart failure on serum thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3'5'-triiodothyronine (reverse T3), free T4, free T3 concentrations, and the serum T4 and T3 concentrations in response to administration of thyrotropin were studied. Serum thyroid hormone concentrations were not different between eight dogs with spontaneous congestive heart failure and normal age matched control dogs. Seven dogs with experimental heart failure were tested before and after induction of congestive heart failure by rapid ventricular pacing. Mean serum T4 and free T3 concentrations were decreased and mean serum reverse T3 concentration was increased following induction of heart failure. The serum T4 and T3 responses to thyrotropin were not altered. Thyroid gland morphology appeared normal in dogs with experimental heart failure. Experimental congestive heart failure, similar to some other nonthyroidal illnesses, alters thyroid hormone secretion and metabolism in dogs.
研究了自发性和实验性诱导的充血性心力衰竭对血清甲状腺素（T4）、3,5,3'-三碘甲状腺原氨酸（T3）、3,3'5'-三碘甲状腺原氨酸（反T3）、游离T4、游离T3浓度以及给予促甲状腺激素后血清T4和T3浓度的影响。八只患有自发性充血性心力衰竭的犬与年龄匹配的正常对照犬之间的血清甲状腺激素浓度没有差异。七只患有实验性心力衰竭的犬在通过快速心室起搏诱导充血性心力衰竭之前和之后进行了测试。心力衰竭诱导后，血清T4和游离T3的平均浓度降低，血清反T3的平均浓度升高。血清T4和T3对促甲状腺激素的反应没有改变。实验性心力衰竭犬的甲状腺形态看起来正常。实验性充血性心力衰竭与其他一些非甲状腺疾病相似，会改变犬的甲状腺激素分泌和代谢。
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