Whittaker P G, Lind T
University Department of Obstetrics and Gynaecology, Princess Mary Maternity Hospital, Newcastle, Tyne, UK.
Br J Obstet Gynaecol. 1993 Jun;100(6):587-92. doi: 10.1111/j.1471-0528.1993.tb15315.x.
To quantify the changes in serum albumin during human pregnancy.
Longitudinal prospective study.
Before conception and antenatal clinic.
Sixty-nine normal women and 23 women with Type 1 diabetes.
Administration of Evans' blue dye and collection of serum samples.
Albumin concentration, plasma volume and intravascular mass of albumin.
In normal subjects serum albumin concentration showed a significant decrease of 1.9 (95% CI 1.0 to 2.9) g/l by 7 weeks gestation with a further 8.2 (95% CI 7.5 to 8.9) g/l decrease by 36 weeks gestation, an overall change of 22%. Plasma volume first increased significantly by 190 (95% CI 105 to 275) ml between 7 and 12 weeks, with a further increase of 1003 (95% CI 871 to 1135) ml between 12 and 36 weeks of pregnancy, a change of 53%. The intravascular mass of albumin showed no change between non-pregnant, 7 and 12 week values but there was a significant rise of 19.5 (95% CI 15.1 to 23.9) g between 12 and 28 weeks of gestation, an overall increase of 19%. Diabetic subjects showed similar changes.
Rather than simply reflecting plasma volume dilution, the changes in serum albumin imply alterations in albumin metabolism during pregnancy.
量化人类妊娠期间血清白蛋白的变化。
纵向前瞻性研究。
受孕前及产前诊所。
69名正常女性和23名1型糖尿病女性。
注射伊文思蓝染料并采集血清样本。
白蛋白浓度、血浆容量和白蛋白血管内质量。
在正常受试者中，妊娠7周时血清白蛋白浓度显著下降1.9（95%可信区间1.0至2.9）g/l，妊娠36周时进一步下降8.2（95%可信区间7.5至8.9）g/l，总体变化为22%。血浆容量在7至12周之间首先显著增加190（95%可信区间105至275）ml，在妊娠12至36周之间进一步增加1003（95%可信区间871至1135）ml，变化为53%。白蛋白血管内质量在非妊娠、7周和12周时无变化，但在妊娠12至28周之间显著增加19.5（95%可信区间15.1至23.9）g，总体增加19%。糖尿病受试者表现出类似变化。
血清白蛋白的变化并非仅仅反映血浆容量稀释，而是意味着妊娠期间白蛋白代谢发生了改变。
