保肾丸治疗长期血液透析慢性肾衰竭的疗效观察

[Effects of baoshen pill in treating chronic renal failure with long-term hemodialysis].

作者信息

Ji S M, Li L S, Ji D X

机构信息

Dept. of Nephrology, Jinling Hospital, Nanjng.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Feb;13(2):71-3, 67.

PMID:8334339

Abstract

A clinical trial, to evaluate the effects of Baoshen Pill (Rheum palmatum extract, RPE) on hemodialytic patients was conducted. 42 cases with terminal stage of renal failure (Scr < 10 ml/min) on HD were divided at random into RPE treated group and control group. The results showed there were no statistically significant differences between two groups for Scr or BUN. Serum levels of TC, LDL-c, apo B and apo B/apo A1 dropped down and HDL-c, apo A1, albumin, pro-albumin and fibrinectin increased during the follow-up period (P < 0.05) in the treated patients. It is considered that the mechanisms of RPE in preventing chronic renal failure were not the action of whole body. Improving serum levels of albumin, lipoprotein, apolipoproteins might play important role in treatment.

摘要

进行了一项评估保肾丸（大黄提取物，RPE）对血液透析患者影响的临床试验。42例终末期肾衰竭（Scr < 10 ml/min）且正在进行血液透析的患者被随机分为RPE治疗组和对照组。结果显示，两组之间的Scr或BUN无统计学显著差异。在随访期间，治疗组患者的血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-c）、载脂蛋白B（apo B）和apo B/apo A1水平下降，而高密度脂蛋白胆固醇（HDL-c）、apo A1、白蛋白、前白蛋白和纤连蛋白水平升高（P < 0.05）。认为RPE预防慢性肾衰竭的机制并非全身作用。改善血清白蛋白、脂蛋白、载脂蛋白水平可能在治疗中起重要作用。