Olsson P O, Arnqvist H, Asplund J
Department of Internal Medicine, Regional Hospital, University of Linköping, Sweden.
Diabet Med. 1993 Jun;10(5):477-80. doi: 10.1111/j.1464-5491.1993.tb00102.x.
This study was designed to investigate whether the indwelling time of the needle during continuous subcutaneous insulin infusion (CSII) could contribute to one of the main problems with subcutaneous insulin administration, that is the day-to-day intra-patient variation in absorption. The effect on insulin kinetics after a bolus dose was investigated at different time intervals up to 4 days after insertion of an indwelling catheter in situ for CSII therapy. Nine insulin-dependent diabetic patients treated with pump (Nordisk Infuser; Velosulin 100 U ml-1) took part in the study. The evening before day 1 of the investigation a needle connected to the pump with a polyethylene catheter was inserted subcutaneously on the abdominal wall where it remained throughout the investigation. There were no significant differences in blood glucose or plasma free insulin profiles between days 1, 3, and 5. The intra-patient coefficient of variation of free insulin was 38% at basal and 19% at post-bolus state. We conclude that during CSII it is acceptable from a pharmacokinetic point of view to retain the infusion site for up to 4 days.
本研究旨在调查持续皮下胰岛素输注（CSII）期间针头的留置时间是否会导致皮下胰岛素给药的主要问题之一，即患者体内每日吸收的差异。在用于CSII治疗的留置导管原位插入后长达4天的不同时间间隔，研究了推注剂量后对胰岛素动力学的影响。九名接受泵治疗（诺和诺德输液器；优泌林100 U/ml）的胰岛素依赖型糖尿病患者参与了该研究。在研究第1天的前一晚，将连接有聚乙烯导管的针头皮下插入腹壁，并在整个研究过程中留置在该处。第1天、第3天和第5天之间的血糖或血浆游离胰岛素水平无显著差异。患者体内游离胰岛素的变异系数在基础状态下为38%，推注后状态下为19%。我们得出结论，从药代动力学角度来看，在CSII期间将输注部位保留长达4天是可以接受的。
