Sriwanthana B, Island M D, Mobley H L
Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201.
Gene. 1993 Jul 15;129(1):103-6. doi: 10.1016/0378-1119(93)90703-6.
We report the sequence of ureG, an accessory gene that is a part of the ure gene cluster of uropathogenic Proteus mirabilis and required for full enzymatic activity of urease. The 615-bp open reading frame predicts a M(r) 22,374 polypeptide, which contains a consensus amino acid (aa) sequence for ATP-binding. The polypeptide shares sequence homology with UreG of Escherichia coli (93% of identical aa), Klebsiella aerogenes (59%) and Helicobacter pylori (59%).
我们报道了ureG基因的序列，该基因是尿路致病性奇异变形杆菌脲酶基因簇的一个辅助基因，对于脲酶的完全酶活性是必需的。这个615 bp的开放阅读框预测出一个分子量为22374的多肽，其包含一个ATP结合的共有氨基酸序列。该多肽与大肠杆菌的UreG（93%的氨基酸相同）、产气克雷伯菌（59%）和幽门螺杆菌（59%）具有序列同源性。
